HHIP, HDAC4, NCR3 and RARB polymorphisms affect fetal, childhood and adult lung function.
نویسندگان
چکیده
Impaired lung function, and consequent respiratory morbidity including asthma and chronic obstructive pulmonary disease, may have their origins in early life [1–3]. Genome-wide analysis studies (GWAS) have identified a number of single-nucleotide polymorphisms (SNPs) in those of European ancestry that affect adult lung function, as measured by forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) ratio. 23 of these SNPs have directionally consistent effects on both FEV1 and FEV1/FVC in children and adults [4].
منابع مشابه
Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development
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ورودعنوان ژورنال:
- The European respiratory journal
دوره 41 3 شماره
صفحات -
تاریخ انتشار 2013